These statements have not been evaluated by the Food and Drug Administration.
Any products or substances mentioned here are not intended to diagnose, treat, cure, or prevent any disease.

Muscadine Health Research Links

Here are numerous links summarizing the incredible research conducted on muscadine grape seeds’ effect on human health. If you are new to the internet, the links below are embedded in the words and you access them by clicking the underlined (or highlighted) words, which will then open the linked websites in a new window.  Using “Ctrl-F” you can “find” a specific document by typing the word(s) for which you’re searching.  (You can also use the Search box at the top-right on this page.)

If you search PubMed.gov, you’ll see that there have been over 2,500 studies on red wine, over 800 studies on grape seeds, and over 600 studies on red grapes.  Red wine and red grapes are incredibly healthy and the studies on heart health and longevity have been nothing short of amazing. But muscadines actually take all the health benefits of the red grape and ‘kick it up a notch’.” – BeachCarolina.com


CLINICAL STUDIES ON ACTUAL PRODUCTS

Currently only one product has had clinical testing completed on it (2 different studies). One other product is currently undergoing testing at Johns Hopkins Univ.

2010 Oct. 1, Study published in Journal of the American College of Nutrition: “Effect of Muscadine Grape Seed Supplementation on Vascular Function in Subjects with or at Risk for Cardiovascular Disease: A Randomized Crossover Trial” (also online at NIH National Library of Medicine) (and PDF copy) (Nature’s Pearl product)

2011 Apr. 5, Study presented at the annual meeting of the American Association for Cancer Research: “Inhibition of Cancer Cell Growth by Muscadine Grape Seed and Grape Skin Extracts(Nature’s Pearl product)

2011 Apr. 5, Article from Davie County, NC, Blog: Local news story covering the results from the second clinical study on Nature’s Pearl extract – “18,000 Scholars, Experts, and Scientists From Around the World Meet On the Front Lines of the Battle Against Cancer” (Nature’s Pearl product)

2011 July (study start date), ClinicalTrials.gov: “Effects of Two Doses of MPX Capsules on Rising Prostate-specific Antigen Levels in Men Following Initial Therapy for Prostate Cancer“ (Muscadine Plus product) (estimated study completion date: June 2014; study mentioned in the May 21, 2012 Washington Post story referenced below)


STUDIES & STORIES ON GRAPES & INGREDIENTS

The links below are organized chronologically (by date):

2003 Aug. 1, Study published in Journal of Agricultural and Food Chemistry: “Phenolic Content and Antioxidant Capacity of Muscadine Grapes” (“Antioxidant capacity values were, on average, 2.4, 12.8, 281.3, and 236.1 μM TEAC/g of FW for pulps, skins, seeds, and leaves, respectively.”)

2005 Mar. 1, Study published in Anticancer Research: “Ellagic Acid Induced … Apoptosis in Human Bladder Cancer

2005 Sep. 3, Book, “Muscadine Medicine,” by Diane Hartle, Ph.D., published September 3, 2005

2005 Nov. 2, Study published in Journal of Agricultural and Food Chemistry: “Study of anticancer activities of muscadine grape phenolics in vitro” (“The objective of this study was to evaluate the effect of phenolic compounds in muscadine grapes on cancer cell viability and apoptosis. … These findings suggest that polyphenols from muscadine grapes may have anticancer properties.“)

2005 Nov. 2, Study published in Journal of Agricultural and Food Chemistry: “Antiinflammatory properties of the muscadine grape” (“The muscadine grape possesses one of the highest antioxidant levels among fruits; yet, the effect of this fruit on mammalian metabolic systems has not received significant attention. … These results demonstrate that the muscadine grape skin powder possesses significant in vitro and in vivo antiinflammatory properties.“)

2006 July 26, Study published in Journal of Agricultural and Food Chemistry: “Induction of cell death in Caco-2 human colon carcinoma cells by ellagic acid rich fractions from muscadine grapes

2007 Feb. 14, Story on The University of Georgia’s Nutraceutical Research Laboratory: receives Georgia Center of Innovation Award for work on nutraceutical value of the muscadine grape

2007 Mar. 1, USDA’s Agricultural Research Service (“The in-house research arm of the U.S. Department of Agriculture“) report: “America’s First Grape: The Muscadine” (“Last Modified: 03/01/2007″)

2007 Aug. 31, Press Release from National Cancer Institute (US Govt.): “Unique Grape Skin Extract Inhibits Prostate Cancer Cell Growth in the Laboratory” (from study published in 2007 Sep. 1 issue of “Cancer Research“)

2007 Oct. 26, Story in ScienceDaily.com: “Could Muscadine Grape Seeds Offer Cardiovascular Benefits?” (“The goal of the current study is to determine if daily doses of the Nature’s Pearl supplement, which is specially prepared to maximize its natural antioxidant and anti-inflammatory concentrations, will have a favorable effect on cardiovascular risk factors,” said David Herrington, M.D., M.P.H., lead investigator and a professor of cardiology.“)

2008 May 1, Study published in The Journal of Nutritional Biochemistry: “Resveratrol inhibits … cell invasion in human breast cancer cells

2008 June 1, Special feature story in M.D. News: “The Health Benefits of Muscadine Grapes, Wines, and Nutraceuticals” (link goes to a PDF)

2008 Nov. 1, Study published in Cancer Prevention Research: “Apoptosis initiated in colon cancer cells when treated with muscadine grape extract
(“Research suggests strong correlations between the inflammation process and colon cancer progression, making it an attractive target for anti-inflammatory drugs and compounds. Muscadines (Vitis rotundifolia), a grape species native to the Southeastern United States, are rich in polyphenols containing many biologically important flavonoids that may have potential anti-inflammatory and anti-oxidant properties. Current research has shown that the muscadine grape has a higher total phenolic and flavonoid content than commercially available red grapes.“)

2009 Jan. 1, Study published in Clinical Cancer Research: “Grape-seed extract kills laboratory leukemia cells, proving value of natural compounds

2009 Sep. 1, Study published in The Journal of Nutrition: “Anticancer and Cancer Chemopreventive Potential of Grape Seed Extract and Other Grape-Based Products

2010, North Carolina Dept. of Agriculture: “Muscadine Brochure” (“The finding that muscadine grapes are naturally high in healthful antioxidants has led to an expansion of the industry in North Carolina. Antioxidants help protect the body from the damaging effects of oxygen free radicals, which can contribute to degenerative diseases.“)

2010, North Carolina Muscadine Grape Association: “Brunswick Biomedical Laboratories of Wareham, Massachusetts stated in 2003 that NutraGrape’s Muscadine Grape Seed has the highest ORAC (Oxygen Radical Absorbing Capacity) of any natural substance they have yet to test.” (link deactivated in 2013)

2010 Mar. 23, Study published in Cancer Prevention Research: “Resveratrol Suppresses Colitis and Colon Cancer Associated with Colitis

2010 May, TED Talk by William Li, Cancer researcher and co-founder of the Angiogenesis Foundation, a nonprofit that is re-conceptualizing global disease fighting: “Can We Eat To Starve Cancer?” (video, 20 minutes); at the 12:30 mark, he mentions grapes, resveratrol, and ellagic acid.  (“Can we eat to starve cancer? The answer is yes. … What we’ve discovered is Mother Nature has laced a large number of foods and beverages, and herbs with naturally occurring inhibitors of angiogenesis.”)

2011 May 5, Story on The Dr. Oz Show: “Why Wild Plants Can Protect You From Cancer,” by Mary Ann Lila, Ph.D., Director, Plants for Human Health Institute, North Carolina State Univ. (“… naturally high inherent concentrations of flavonoids (resveratrol, quercetin and ellagic acid) make these grapes naturally resistant to many of the diseases that plague other types of grapes – and these same compounds are what make muscadine grapes so protective against many different types of human cancers..”)

2011, July 15, Study published in The Journal of Alzheimer’s Disease: “Natural Chemical Found In Grapes May Protect Against Alzheimer’s Disease by Decreasing Neurotoxins in the Brain” (pubmed link) (“This is the first study to evaluate the ability of grape-derived polyphenols to prevent the generation of a specific form of β-amyloid (Aβ) peptide, a substance in the brain long known to cause the neurotoxicity associated with Alzheimer disease. … Previous studies suggest that increased consumption of grape-derived polyphenols, whose content, for example, is very high in red wine, may protect against cognitive decline in Alzheimer’s. This new finding, showing a selective decrease in the neurotoxin Aβ*56 following grape-derived polyphenols treatment, corroborates those theories. … ‘Since naturally occurring polyphenols are also generally commercially available as nutritional supplements and have negligible adverse events even after prolonged periods of treatment, this new finding holds significant promise as a preventive method or treatment …’“)

2011 Aug. 2, Story on Charlotte, NC, Fox TV Station: “N.C. State Fruit The Cure To Cancer?(PDF of original site; see 2-minute video here)  (“… acres of muscadine vines, a thriving part of the North Carolina economy, and according to some doctors the secret to beating cancer.  ‘Absolutely, no question about it,’ says Dr. Larry Pearce a Neurologist. Dr. Pearce has spent most of his career as a neurologist studying how drugs affect the brain, now he focuses on how natural chemicals found in muscadines can prevent cancers before they start.“)

2011 Aug. 11, Story on LiveStrong.com: “Health Benefits of Muscadine Grapes

2011 Oct. 14, Story published by the University of Florida:  “UF grape researcher wins $2.2 million grant to create consumer-friendly muscadines

2011 Oct. 21, Story on The Dr. Oz Show: “Quick Fixes to Prevent the Diseases You Fear Most” (“Fight back against the second leading cause of death: cancer.  Full of antioxidants, grape seed extract helps protect your cells from free radicals, which can damage cells.  Lab studies have also shown that grape seed extract may help prevent breast and colon cancer.”)

2012 Jan. 26, Study published in the journal Carcinogenesis: “Grape seed extract kills head and neck cancer cells, leaves healthy cells unharmed

2012 Mar. 15, Article from The Outer Banks Voice: “Muscadine grape shows promise in fighting cancer

2012 Apr. 26, Research presented at the “2012 Experimental Biology Conference“: “Grape Consumption May Offer Benefits for Anxiety and Related Hypertension, Learning and Memory Impairments” (“Grape antioxidants may defend against contributing oxidative stress“)

2012 Apr. 26, Study published in the journal The American Journal of Cardiology: “Resveratrol-rich grape extract shows heart health benefits: Human data” (“the longest human trial reported thus far using a resveratrol-containing product“)

2012 May 21, Article from The Washington Post: “Cancer Doctors Put Competition Aside To Share Treatment Options For Their Patients” (“… specialists were exchanging notes about drugs, radiation, and muscadine grape skin extract for a disease that strikes two of every three men older than 65“)

2012 May 21, From the W. Post story above, proof that Johns Hopkins Univ. is conducting the clinical study with a muscadine supplement: “Effects of Two Doses of MPX Capsules on Rising Prostate-specific Antigen Levels in Men Following Initial Therapy for Prostate Cancer

2012 Oct. 24, Article from The Southern Pines Pilot: “Stomping Out the Truth About Grape Seed Supplements

2012 Nov. 16, Statement by Medical University of South Carolina Cancer Researcher Mehrdad Rahmaniyan, M.D., on muscadine health benefits: “Muscadine Grape and its Antioxidant Activity

2012 Dec 17, Article from 303Magazine.com: “Hot To Squat: Exceedingly Good Seed

2013 Jan. 7, Study published in the “Journal of Applied Microbiology” doi: 10.1111/jam.12129: “Activities of Muscadine Grape Skin and Polyphenolic Constituents against Helicobacter pylori” Department of Biological Sciences, Clemson University, Clemson, SC (Pubmed link)

2013 Feb. 20, Article from BeachCarolina.com: “Conference to Present a Discussion on Value-Added Products from Muscadine Grapes

2013 March 15th, Article from GreenMedInfo.com: “Grape Seed Extract May Beat Chemo in Late-Stage Cancer

2013 Apr. 22, Study presented at the “Experimental Biology conference”: “Grape intake may protect against metabolic syndrome-related organ damage,” University of Michigan Health System; (“Study shows grapes reduced inflammation and fat storage, improved antioxidant defense.“)

2013 May 6, MedicalNewsToday.com story on study published in the “Journal of Nutritional Biochemistry“: “Grapes Activate Genes Responsible For Antioxidant Defense In The Heart“; (“A study appearing in the Journal of Nutritional Biochemistry demonstrates that grapes are able to reduce heart failure associated with chronic high blood pressure (hypertension) by increasing the activity of several genes responsible for antioxidant defense in the heart tissue.“)

2013 Nov. 19, Study published in the “Journal of Proteome Research“: “iTRAQ-Based Quantitative Proteomics of Developing and Ripening Muscadine Grape Berry,” The Center for Viticulture and Small Fruit Research, Florida A&M University, and earlier this year presented at “the largest Ag-Genomics Meeting in the world,” and supported by a USDA/CBG grant; (The study found “statistically significant changes in the berry proteome, detecting a total of 674 proteins“; “Detailed analysis of function-related protein profiles helped discover a set of proteins that appears to play key roles in regulating enological and disease tolerance characteristics of grape berry.”  The publication uses the term “muscadine berry” numerous times, which is also noteworthy.)

2014 Mar. 12, Study published in BiomedCentral.com’s “Complementary and Alternative Medicine“: “Muscadine grape skin extract reverts snail-mediated epithelial mesenchymal transition via superoxide species in human prostate cancer cells,” study also published on the Emory University site. (The study “shows that … therapeutic targeting of Snail with various antioxidants such as MSKE [muscadine grape skin extract] may prove beneficial in abrogating EMT and ROS-mediated tumor progression in human prostate cancer.

2014 Apr 30, Livestrong.com story: “Health Benefits of Muscadine Grapes“; (“When you pop into your local market for some grapes, you’re far more likely to head home with the green or red seedless variety than with a bunch of muscadines. Although muscadine grapes aren’t as widely available as other varieties, they’re worth seeking out — muscadines are significantly more nutritious than the average table grape.“)

2014 Apr 30, Livestrong.com video: “Cary Williams: Value of Muscadine Seeds” (1 min.); Cary Williams is a current Olympic-certified boxing trainer, fitness expert and speaker. She has been writing since 2001 and has contributed to publications including “Oxygen,” “USA Today” and “Fitness.” (“Hi, I’m Cary Williams, and we’re talking today about the value of muscadine seeds. So muscadine seeds are really like your grape extract. Everybody likes to drink wine but this is something you can take to have the benefits of wine without the alcohol, and it’s really an anti-inflammatory. So the use really is anti-aging. You want to look younger, feel great, this is the product that you want. It comes in pill form. Again, it’s a natural remedy for anti-aging, anti-inflammatory. That’s all you need. You don’t have to go home and drink wine. You can do all this without the alcohol and that’s what your muscadine seed is.“)

2014 May 12, Florida A&M University (Facebook page) story: “FAMU Student Scientist First to Clone Muscadine Grape Gene“, story also ran in Highlands Today/Tampa Tribune, “Florida A&M student wins recognition for innovative research“, and on FreshPlaza.com. (“Florida A&M University (FAMU) College of Agriculture and Food Sciences student Jasmine A. Hall is the first young scientist to clone the Flavanone 3′ Hydroxylase (F3’H) gene from muscadine grapes. … Hall’s groundbreaking accomplishment is a part of ongoing research at FAMU’s Center of Viticulture and Small Fruit Research that has uncovered the multiple health benefits of the super food. … ‘Muscadine grapes, or ‘bullets,’ are a common fruit that many people in the South grew up eating,’ said Hall, a fourth-year food science student. ‘This research enables us to capitalize on the nutritional benefits of the muscadine grape, which has one of the highest antioxidant levels amongst fruits.’“)

2014 May 12, StarNewsOnline.com story: “Port City Foodies: Local grapes find new use.” (“JUVN8 smoothies are made from muscadine grapes and other fruits grown at Cottle Farms in Faison.” “The whole thing came to be because we grow muscadine grapes on our farm, and a lot of people like all of the healthy antioxidants in them … But a lot of those properties are coming from the seeds and skins. We found these big industrial choppers and emulsifiers from Urschel Labs in Indiana, and we’re actually pureeing the whole grape whereas most just press them for the juice.” “The blueberry is a whole different game. Composed of a very specific 48 berries and 12 muscadine grapes per bottle, I’ve thoroughly enjoyed gulping down this flavorful brew after a morning jog and weightlifting session.“)

2014 May 27, Study published in the “Journal of Agriculture & Food Chemistry“: “Antioxidant, Antibacterial, and Antibiofilm Properties of Polyphenols from Muscadine Grape (Vitis rotundifolia Michx.) Pomace against Selected Foodborne Pathogens.” (“Results showed that antioxidant activity for different polyphenols varied greatly … Antioxidant and antibacterial activities for polyphenols showed a positive correlation. Muscadine polyphenols exhibited a broad spectrum of antibacterial activity against tested foodborne pathogens, especially Staphylococcus aureus. Muscadine polyphenols … caused a … drop in cell viability for S. aureus in 6 h with lysis, whereas at 0.5 × MIC they inhibited its biofilm formation and at 16 × MIC they eradicated biofilms. Muscadine polyphenols showed synergy with antibiotics and maximally caused a … drop in cell viability at subinhibitory concentration.“)

2014 June 11, InfoBarrel.com story: “How to Grow Muscadine Grapes in Your Garden.” (“Many novice gardeners are advised to begin with a Muscadine vine because it is so easy to grow and thrives in many harsh conditions. It particularly does well in the southeastern portion of the United States. The vines typically produce beautiful black, purple, pink, red, green or even bronze colored grapes. Best of all, they are very nutritious and provide many health benefits …“)

2014 June 17, Study published by the University of Florida’s “Institute of Food and Agricultural Sciences“: “UF/IFAS study shows promise for antioxidants extracted from grape seeds, skin,” study also published on the Emory University site. (“Soaking muscadine grape seeds or skins in a solution of enzymes can boost antioxidants extracted from the fruit, creating possible new uses for grape leftovers, which are loaded with nutrients, a University of Florida study shows”; “The study was published in the February online edition of the journal Food Chemistry and is scheduled to be in the journal’s print edition in August.“) The study was also reported in the following online locations:


These statements have not been evaluated by the Food and Drug Administration.
Any products or substances mentioned here are not intended to diagnose, treat, cure, or prevent any disease.

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